Publications

2,558 citations · h-index 10 (as of July 2026) · full record and citation metrics on Google Scholar

Peer-reviewed publications

• Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia
  Aryal, S., Geng, C., Yin, M.A., Kwon, M.J., Farsi, Z., et al. · Cell Reports 45(6), 2026
  Found that partial loss of the schizophrenia risk gene Srrm2 disrupts RNA splicing in the mouse brain, causing selective loss of a specific SynGAP protein isoform, mis-splicing of its interactor Agap3, and reduced oligodendrocyte numbers — linking a splicing-factor gene to both synaptic and myelination deficits relevant to schizophrenia.
• Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder
  Song, B.J., Ge, Y., Nicolella, A., et al., Aryal, S., et al., Sheng, M. · Nature Communications 16(1), 10793, 2025
• Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus
  Perzel Mandell, K.A., Simmons, S.K., Nadig, A., Farsi, Z., Huang, W.C., Aryal, S., et al. · Translational Psychiatry 15(1), 345, 2025
• Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
  Farsi, Z., Nicolella, A., Simmons, S.K., Aryal, S., Shepard, N., et al. · Neuron 111(21), 3378–3396, 2023
• Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice
  Longo, F., Aryal, S., Anastasiades, P.G., Maltese, M., Baimel, C., et al. · Cell Reports 42(8), 112901, 2023
  Showed that dysregulated protein synthesis at cortico-striatal synapses drives repetitive behaviors in a fragile X syndrome mouse model, pinpointing specific striatal neuron types and dysregulated mRNAs as potential therapeutic targets.
• Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model
  Aryal, S., Bonanno, K., Song, B., Mani, D.R., Keshishian, H., Carr, S.A., Sheng, M., Dejanovic, B. · Cell Reports 42(5), 112497, 2023
  Deep proteomic profiling of synapses from 105 human brains found that schizophrenia and bipolar disorder share substantial synaptic protein alterations, several of which are recapitulated in an Akap11 mouse model of both disorders.
• Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
  Longo, F., Mancini, M., Ibraheem, P.L., Aryal, S., Mesini, C., et al. · Molecular Psychiatry 26(11), 6427–6450, 2021
• Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice
  Aryal, S., Longo, F., Klann, E. · Proceedings of the National Academy of Sciences 118(18), e2001681118, 2021
  Used ribosome profiling to show that fragile X mouse brain has coding-sequence-length-dependent alterations in mRNA translation efficiency, and that genetically removing the kinase S6K1 corrects this defect.
• Moving beyond P values: data analysis with estimation graphics
  Ho, J., Tumkaya, T., Aryal, S., Choi, H., Claridge-Chang, A. · Nature Methods 16(7), 565–566, 2019
• Altered steady state and activity-dependent de novo protein expression in fragile X syndrome
  Bowling, H., Bhattacharya, A., Zhang, G., et al., including Aryal, S., Klann, E. · Nature Communications 10(1), 1710, 2019
• Turning up translation in fragile X syndrome Perspective
  Aryal, S., Klann, E. · Science 361(6403), 648–649, 2018
  A Perspective on Greenblatt & Spradling's finding that FMRP increases translation of long mRNAs in Drosophila oocytes, discussing implications for understanding translational control in fragile X syndrome and autism.
• Ancient anxiety pathways influence Drosophila defense behaviors
  Mohammad, F., Aryal, S., Ho, J., Stewart, J.C., Norman, N.A., et al. · Current Biology 26(7), 981–986, 2016
  Showed that Drosophila display an anxiety-like wall-hugging behavior modulated by GABA receptor and serotonin signaling, establishing flies as a genetic model for studying conserved anxiety circuits.

Preprints

• Spatially resolved translational dysregulation in Grin2a^+/− mouse model of schizophrenia Preprint
  Wu, M., Huang, J., Aryal, S., Farsi, Z., Chen, H., et al. · bioRxiv, 2025
• GPR34 regulation of disease-associated microglial states and responses to physiological stimuli Preprint
  Geller, A., Kwon, M.J., Simmons, S.K., et al., Aryal, S., et al., Kunwar, P.S. · bioRxiv, 2025
• Epigenetic changes, neuronal dysregulation and metabolomic abnormalities in Zmym2 mutant mice, a genetic model of schizophrenia and neurodevelopmental disorder Preprint
  Huang, W.C., Perzel Mandell, K., Aryal, S., Song, B.J., Valle-Tojeiro, A., et al. · bioRxiv, 2025
• Brain-region-specific changes and dysregulation of activity regulated genes in Gria3 mutant mice, a genetic animal model of schizophrenia Preprint
  Huang, W.C., Kast, R., Perzel Mandell, K., Dejanovic, B., Bonanno, K., Aryal, S., et al. · bioRxiv, 2024
• Multi-omics characterization reveals brain-wide disruption of synapses and region- and age-specific changes in neurons and glia in Sp4 mutant mice, a genetic model Preprint
  Kwon, M.J., Perzel Mandell, K.A., Aryal, S., Geng, C., Nicolella, A.A., et al. · bioRxiv, 2024
• Synaptic composition, activity, mRNA translation and dynamics in combined single-synapse profiling using multimodal imaging Preprint
  Falkovich, R., Aryal, S., Wang, J., Sheng, M., Bathe, M. · bioRxiv, 2024
  Contributed to a multimodal single-synapse imaging method linking local mRNA translation, synaptic protein composition, and synaptic activity at individual synapses, applied to map how NMDA receptor loss-of-function rewires synaptic signaling in a Grin2a schizophrenia model.

Publication data via Google Scholar and PubMed.